Howling II: ... Your Sister Is a Werewolf (1985)

After countless millennia of watching, waiting and stalking, the unholy creatures known as werewolves are poised to inherit the earth. After newswoman Karen White's shocking on-screen transformation and violent death, her brother Ben is approached by Stefan Crosscoe, a mysterious gentleman who claims that Karen has actually become a werewolf. But this is the least of their worries... To save mankind, Stefan and Ben must travel to Transylvania to battle and destroy Stirba, the immortal queen of all werewolves, before she is restored to her full powers!